Read the latest publications from our research team here.
Developing Novel Host-Based Therapies Targeting Microbicidal Responses in Macrophages and Neutrophils to Combat Bacterial Antimicrobial Resistance.
Watson K, Russell CD, Baillie JK, Dhaliwal K, Fitzgerald JR, Mitchell TJ, Simpson AJ, Renshaw SA, Dockrell DH.
Front Immunol. 2020 Jun 5;11:786. PMID: 32582139
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Polymersomes Eradicating Intracellular Bacteria.
Fenaroli F, Robertson JD, Scarpa E, Gouveia VM, Di Guglielmo C, De Pace C, Elks PM, Poma A, Evangelopoulos D, Canseco JO, Prajsnar TK, Marriott HM, Dockrell DH, Foster SJ, McHugh TD, Renshaw SA, Martí JS, Battaglia G, Rizzello L.
ACS Nano. 2020 Jun 19. doi: 10.1021/acsnano.0c01870. Online ahead of print. PMID: 32515944
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Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection
Li B, Clohisey SM, Chia BS, Wang B, Cui A, Eisenhaure T, Schweitzer LD, Hoover P, Parkinson NJ, Nachshon A, Smith N, Regan T, Farr D, Gutmann MU, Bukhari SI, Law A, Sangesland M, Gat-Viks I, Digard P, Vasudevan S, Lingwood D, Dockrell DH, Doench JG, Baillie JK & Hacohen N.
Nature Communications. 2020 Jan 9;11(1):164. PMID: 31919360
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Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation
Hellyer TP, McAuley DF, Walsh TS, Anderson N, Conway Morris A, Singh S , […] Bowett SA, Simpson AJ.
Lancet Respir Med. 2020 Feb;8(2):182-191. PMID: 31810865
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Macrophages utilize mitochondrial fission to enhance mROS production during responses to Streptococcus pneumoniae
Mohasin M, Balbirnie-Cumming K, Fisk E, Prestwich EC, Russell CD, Marshall J, Pridans, Allen SP, Shaw PJ, De Vos KJ, Hill CJ, Bullough P, Condliffe AM, Mitchell TJ, Marriott HM, Dockrell DH
bioRꭙiv (2019)
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Neutrophils use selective autophagy receptor p62 to target Staphylococcus aureus for degradation in the zebrafish model
Gibson JF, Prajsnar TK, Serba JJ, Tonge RD, Grierson AJ, Ingham PW, Renshaw SA, Johnston SA.
bioRꭙiv (2019) in press
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Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation.
Rahman A, Henry KM, Herman KD, Thompson AA, Isles HM, Tulotta C, Sammut D, Rougeot JJ, Khoshaein N, Reese AE, Higgins K, Tabor C, Sabroe I, Zuercher WJ, Savage CO, Meijer AH, Whyte MK, Dockrell DH, Renshaw SA, Prince LR.
Elife, 15;8 (Oct 2019)
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Pellino-1 Regulates Immune Responses to Haemophilus influenzae in Models of Inflammatory Lung Disease
Hughes BM, Burton CS, Reese A, Jabeen MF, Wright C, Willis J, Koshaein N, Marsh EK, Peachell P, SunSC, Dockrell DH, Marriott HM, Sabroe I, Condliffe AM, Prince LR
Frontiers in Immunology, 31;10:1721 (July 2019)
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Alveolar Macrophage Apoptosis-associated Bacterial Killing Helps Prevent Murine Pneumonia.
Preston JA, Bewley MA, Marriott HM, McGarry Houghton A, Mohasin M, Jubrail J, Morris L, Stephenson YL, Cross S, Greaves DR, Craig RW, van Rooijen N, Bingle CD, Read RC, Mitchell TJ, Whyte MKB, Shapiro SD, Dockrell DH.
Am J Respir Crit Care Med, 1;200(1):84-97 (July 2019)
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A transgenic zebrafish line for in vivo visualisation of neutrophil myeloperoxidase
Buchan KD, Prajsnar TK, Ogryzko NV, de Jong NWM, van Gent M, Kolata J, Foster SJ, van Strijp JAG, Renshaw SA
PLoS One, 14(4):e0215592 (April 2019)
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Staphylococcus aureus: setting its sights on the human innate immune system
Buchan KD, Foster SJ, Renshaw SA
Microbiology, 165(4):367-385 (April 2019)
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Lipopolysaccharide inhalation recruits monocytes and dendritic cell subsets to the alveolar airspace
Jardine L, Wiscombe S, Reynolds G, McDonald D, Fuller A, Green K, Filby A, Forrest I, Ruchaud-Sparagano MH, Scott J, Collin M, Haniffa M, Simpson AJ.
Nat Commun, 30;10(1) (April 2019)
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CFTR Protects against Mycobacterium abscessus Infection by Fine-Tuning Host Oxidative Defenses
Bernut A, Dupont C, Ogryzko NV, Neyret A, Herrmann JL, Floto RA, Renshaw SA, Kremer L
Cell Reports, 26(7):1828-1840 (Feb 2019)
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Randomised controlled trial of GM-CSF in critically ill patients with impaired neutrophil phagocytosis.
Pinder EM, Rostron AJ, Hellyer TP, Ruchaud-Sparagano MH, Scott J, Macfarlane JG, Wiscombe S, Widdrington JD, Roy AI, Linnett VC, Baudouin SV, Wright SE, Chadwick T, Fouweather T, Juss JK, Chilvers ER, Bowett SA, Parker J, McAuley DF, Conway Morris A, Simpson AJ.
Thorax, 73:918-925 (Oct 2018)
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Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists.
Bewley MA, Budd RC, Ryan E, Cole J, Collini P, Marshall J, Kolsum U, Beech G, Emes RD, Tcherniaeva I, Berbers GAM, Walmsley SR, Donaldson G, Wedzicha JA, Kilty I, Rumsey W, Sanchez Y, Brightling CE, Donnelly LE, Barnes PJ, Singh D, Whyte MKB, Dockrell DH; COPDMAP.
Am J Respir Crit Care Med, 15;198(6):739-750 (Sept 2018)
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Exposure of monocytic cells to lipopolysaccharide induces coordinated endotoxin tolerance, mitochondrial biogenesis, mitophagy and antioxidant defences.
Widdrington JD, Gomez-Duran A, Pyle A, Ruchaud-Sparagano MH, Scott J, Baudouin SV, Rostron AJ, Lovat P, Chinnery PF, Simpson AJ.
Front Immunol, 9:2217 (Sept 2018)
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Excess mucin impairs subglottic epithelial host defense in mechanically ventilated patients.
Powell J, Garnett J, Mather MW, Cooles FAH, Nelson A, Verdon B, Scott J, Jiwa K, Ruchaud-Sparagano MH, Cummings SP, Perry JD, Wright SE, Wilson JA, Pearson J, Ward C, Simpson AJ.
Am J Respir Crit Care Med, 198:340-349 (Aug 2018)
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HIV gp120 in Lungs of ART-treated Individuals Impairs Alveolar Macrophage Responses To Pneumococci
Collini PJ, Bewley MA, Mohasin M, Marriott HM, Miller RF, Geretti AM, Beloukas A, Papadimitropoulos A, Read RC, Noursadeghi M, Dockrell DH
American Journal of Respiratory and Critical Care Medicine, 197(12):1604-1615 (June 2018)
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Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses
Sadiku P, Willson JA, Dickinson RS, Murphy F, Harris AJ, Lewis A […], Walmsley SR.
The Journal of Clinical Investigation, 127 (9), pp. 3407-3420 (2017)
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Pseudomonas expression of an oxygen sensing prolyl hydroxylase homologue regulates neutrophil host responses in vitro and in vivo
Dickinson RS, Murphy F, Doherty C, Williams S, Mirchandani A, Willson J, Scotti JS, Preston G, Schofield CJ, Whyte MKB, Walmsley SR.
Wellcome Open Research, pp. 104 (2017)
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Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages
Bewley MA, Preston JA, Mohasin M, Marriott HM, Budd RC, Swales J […], Whyte MKB, Dockrell DH.
American Journal of Respiratory and Critical Care Medicine, 196 (7), pp. 845-855 (Oct 2017)
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Mitochondrial DNA depletion induces innate immune dysfunction rescued by interferon-γ.
Widdrington JD, Gomez-Duran A, Steyn J, Pyle A, Ruchaud-Sparagano MH, Scott J, Baudouin SV, Rostron AJ, *Simpson J, *Chinnery PF. *=joint senior authors.
J Allergy Clin Immunol, 140: 1461-1464 (June 2017)
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Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism.
Thompson AA, Dickinson RS, Murphy F, Thomson JP, Marriott HM, Tavares A, […] Whyte MK, Walmsley SR.
Science Immunology, 10;2(8) (Feb 2017)
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OTHER SHIELD INVESTIGATOR PAPERS:
A mathematical model shows macrophages delay Staphylococcus aureus replication, but limitations in microbicidal capacity restrict bacterial clearance.
Best A, Jubrail J, Boots M, Dockrell DH, Marriott HJ.
J Theor Biol. 2020 Jul 21;497:110256. PMID: 32304686
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One Health: a multifaceted concept combining diverse approaches to prevent and control antimicrobial resistance.
L Guardabassi, Butaye P, Dockrell DH, Fitzgerald JR, Kuijper EJ. ESCMID Study Group for Veterinary Microbiology (ESGVM); ESCMID Study Group for Host and Microbiota Interaction (ESGHAMI).
Clin Microbiol Infect. 2020 Jul 20:S1198-743X(20)30418-3. doi: 10.1016/j.cmi.2020.07.012. online ahead of print. PMID: 32702500
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Identifying severe cases of covid-19 in the community.
Quinn T, Craven T, Dockrell DH, Walsh T, Guthrie B, McKinstry B, Dhaliwal K.
BMJ 2020: BMJopinion
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Rate of replenishment and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages.
Bain CC, Gibson DA, Steers NJ, Boufea K, Louwe PA, Doherty C, González-Huici V, Gentek R, Magalhaes-Pinto M, Shaw T, Bajénoff M, Bénézech C, Walmsley SR, Dockrell DH, Saunders PTK, Batada NN, Jenkins SJ.
Sci Immunol. 2020 Jun 19;5(48). PMID: 32561560
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100 years of influenza research seen through the lens of Covid-19.
Bogaert D, Dockrell DH.
Mucosal Immunol. 2020 Jul;13(4):561-562PMID: 32358574
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The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia.
Kitchen GB, Cunningham PS, Poolman TM, Iqbal M, Maidstone R, Baxter M, Bagnall J, Begley N, Saer B, Hussell T, Matthews LV, Dockrell DH, Durrington HJ, Gibbs JE, Blaikley JF, Loudon AS, Ray DW.
Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1543-1551. PMID: 31900362
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Tractable targets for meropenem-sparing antimicrobial stewardship interventions.
Russell CD, Laurenson IF, Evans MH, Mackintosh CL
Journal of Antimicrobial Chemotherapy 2019; 1(2): dlz042 (2019) in press
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Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages.
Belchamber KBR, Singh R, Batista CM, Whyte MK, Dockrell DH, Kilty I, Robinson MJ, Wedzicha JA, Barnes PJ, Donnelly LE; COPD-MAP consortium.
European Respiratory Journal, 10;54(4) (Oct 2019)
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Human Rhinovirus Inhibits Macrophage Phagocytosis of Bacteria in Chronic Obstructive Pulmonary Disease. More Than a Common Cold.
Sabroe I, Ho A, Dockrell DH.
Am J Respir Crit Care Med, 15;199(12):1451-1452 (June 2019)
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The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases: A systematic review and meta-analysis.
Russell CD, Parajuli A, Gale HJ, Bulteel NS, Schuetz P, de Jager CPC, Loonen AJM, Merekoulias GI, Baillie JK
Journal of Infection, 78(5):339-348 (May 2019)
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Comparison of data-acquisition methods for the identification and quantification of histone post-translational modifications on a Q Exactive HF hybrid quadrupole Orbitrap mass spectrometer.
Cole J, Hanson EJ, James DC, Dockrell DH, Dickman MJ.
Rapid Commununication in Mass Spectrometry, 30;33(10):897-906 (May 2019)
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Phenotypic and molecular detection methods for carbapenemase-producing organisms and their clinical significance at two Scottish tertiary care hospitals.
Toner G, Russell CD, Hamilton F, Templeton K, Laurenson IF
Journal of Medical Microbiology, 68(4):560-565 (April 2019)
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A switch in surface polymer biogenesis triggers growth-phase-dependent and antibiotic-induced bacteriolysis.
Flores-Kim J, Dobihal GS, Fenton A, Rudner DZ, Bernhardt TG.
Elife, 9;8 (Apr 2019)
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Early PREdiction of sepsis using leukocyte surface biomarkers: the ExPRES-sepsis cohort study
Shankar-Hari M, Datta D, Wilson J, Assi V, Stephen J, Weir CJ, Rennie J, Antonelli J, Bateman A, Felton JM, Warner N, Judge K, Keenan J, Wang A, Burpee T, Brown AK, Lewis SM, Mare T, Roy AI, Wright J, Hulme G, Dimmick I, Gray A, Rossi AG, Simpson AJ, Conway Morris A, Walsh TS.
Intensive Care Med, 44:627-635 (Nov 2018)
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MacP, a regulator of the cell wall assembly in the human bacterial pathogen Streptococcus pneumoniae.
Manuse S, Fenton A, Grangeasse C.
Med Sci (Paris), 34(8-9):642-645 (Aug-Sept 2018)
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Human skin commensals augment Staphylococcus aureus pathogenesis.
Boldock E, Surewaard BGJ, Shamarina D, Na M, Fei Y, Ali A, Williams A, Pollitt EJG, Szkuta P, Morris P, Prajsnar TK, McCoy KD, Jin T, Dockrell DH, van Strijp JAG, Kubes P, Renshaw SA, Foster SJ.
Nature Microbiology, 3(8):881-890 (Aug 2018)
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Cell surface signatures of immune dysfunction risk stratify critically ill patients: INFECT Study.
Conway Morris A, Datta D, Shankar-Hari M, Stephen J, Weir CJ, Rennie J, Antonelli J, Bateman A, Warner N, Judge K, Keenan J, Wang A, Burpee T, Brown KA, Lewis SM, Mare T, Roy AI, Hulme G, Dimmick I, Rossi AG, Simpson AJ, Walsh TS.
Intensive Care Med, 44:627-635 (May 2018)
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Phosphorylation-dependent activation of the cell wall synthase PBP2a in Streptococcus pneumoniae by MacP.
Fenton AK, Manuse S, Flores-Kim J, Garcia PS, Mercy C, Grangeasse C, Bernhardt TG, Rudner, DZ.
Proc Natl Acad Sci U S A, 13;115(11):2812-2817 (Mar 2018)
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Bacterial size matters: Multiple mechanisms controlling septum cleavage and diplococcus formation are critical for the virulence of the opportunistic pathogen Enterococcus faecalis.
Salamaga B, Prajsnar TK, Jareño-Martinez A, Willemse J, Bewley MA, Chau F, Ben Belkacem T, Meijer AH, Dockrell DH, Renshaw SA, Mesnage S.
PLoS Pathogens, 24;13(7):e1006526 (2017)
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The therapeutic potential of epigenetic manipulation during infectious diseases.
Cole J, Morris P, Dickman MJ, Dockrell DH.
Pharmacology & Therapeutics, 167:85-99 (2016)
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SHIELD AMR Research Consortium 